Complementary DNA cloning of complement C8 beta and its sequence homology to C9.

@article{Haefliger1987ComplementaryDC,
  title={Complementary DNA cloning of complement C8 beta and its sequence homology to C9.},
  author={Jaques Antoine Haefliger and Jurg Tschopp and Denise Nardelli and Walter Wahli and Hans Peter Kocher and Mario Tosi and Keith K. Stanley},
  journal={Biochemistry},
  year={1987},
  volume={26 12},
  pages={3551-6}
}
The complete amino acid sequence of mature C8 beta has been derived from the DNA sequence of a cDNA clone identified by expression screening of a human liver cDNA library. Comparison with the amino acid sequence of C9 shows an overall homology with few deletions and insertions. In particular, the cysteine-rich domains and membrane-inserting regions of C9 are well conserved. These findings are discussed in relation to a possible mechanism of membrane attack complex formation.