Complement triggers relocation of Mortalin/GRP75 from mitochondria to the plasma membrane.

Abstract

Mortalin/GRP75 is a ubiquitously expressed mitochondrial chaperon that is overexpressed in cancer. Mortalin protects cells from complement-dependent cytotoxicity (CDC) and facilitates elimination of the complement C5b-9 complexes from the cell surface. We performed a nanoscopical study aimed at imaging the distribution of the C5b-9 complexes in the plasma… (More)
DOI: 10.1016/j.imbio.2016.07.005

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