Complement system protein C4 and susceptibility to hydralazine-induced systemic lupus erythematosus.

@article{Speirs1989ComplementSP,
  title={Complement system protein C4 and susceptibility to hydralazine-induced systemic lupus erythematosus.},
  author={C J Speirs and Angela H. L. Fielder and Helen Chapel and Nicholas J Davey and J. Richard Batchelor},
  journal={Lancet},
  year={1989},
  volume={1 8644},
  pages={922-4}
}
21 patients with systemic lupus erythematosus induced by long-term treatment with hydralazine were investigated to see whether susceptibility to this syndrome was associated with deficiency of the classical pathway complement protein, C4. 16 of 21 (76%) patients had one or more C4 null (ie, non-productive) alleles compared with 35 of 82 normal subjects (43%). This difference was significant. The HLA-DR4 antigen, known to be in linkage disequilibrium with the C4B null allele, was also… CONTINUE READING

From This Paper

Topics from this paper.
12 Citations
0 References
Similar Papers