Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins.

@article{Kraiczy2004ComplementRO,
  title={Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins.},
  author={Peter Kraiczy and Jens Hellwage and Christine Skerka and Heiko Becker and Michael Kirschfink and Markus Michael Simon and Volker Brade and Peter F Zipfel and Reinhard Wallich},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 4},
  pages={2421-9}
}
The etiologic agent of Lyme disease, Borrelia burgdorferi, is capable of circumventing the immune defense of a variety of potential vertebrate hosts. Previous work has shown that interaction of host-derived complement regulators, factor H and factor H-like protein 1 (FHL-1), with up to five complement regulator-acquiring surface proteins (CRASPs) expressed by resistant B. burgdorferi sensu lato isolates conferred complement resistance. In addition expression of CRASP-1 is directly correlated… CONTINUE READING

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