Complement regulatory protein Crry/p65 costimulation expands natural treg cells with enhanced suppressive properties in proteoglycan-induced arthritis.

@article{Ojeda2011ComplementRP,
  title={Complement regulatory protein Crry/p65 costimulation expands natural treg cells with enhanced suppressive properties in proteoglycan-induced arthritis.},
  author={G. Ojeda and E. Pini and C. Eguiluz and M. Montes-Casado and F. Broere and W. van Eden and J. Rojo and P. Portol{\'e}s},
  journal={Arthritis and rheumatism},
  year={2011},
  volume={63 6},
  pages={
          1562-72
        }
}
OBJECTIVE To investigate the costimulatory role of Crry/p65 (Crry), a membrane complement regulatory protein, on the expansion and function of natural Treg cells and their ability to ameliorate proteoglycan-induced arthritis (PGIA), an animal model of inflammatory arthritis in which the role of natural Treg cells is not well established. METHODS CD4+CD25+ natural Treg cells from BALB/c mice were activated in vitro and costimulated by Crry. The expanded cells were phenotypically characterized… Expand
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