Complement regulatory protein CD46 protects against choroidal neovascularization in mice.

Abstract

Dysregulation of the complement system is increasingly recognized as a contributing factor in age-related macular degeneration. Although the complement regulator CD46 is expressed ubiquitously in humans, in mouse it was previously thought to be expressed only on spermatozoa. We detected CD46 mRNA and protein in the posterior ocular segment (neuronal retina… (More)
DOI: 10.1016/j.ajpath.2014.06.001

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