Complement regulator-acquiring surface protein 1 imparts resistance to human serum in Borrelia burgdorferi.

@article{Brooks2005ComplementRS,
  title={Complement regulator-acquiring surface protein 1 imparts resistance to human serum in Borrelia burgdorferi.},
  author={Chad S. Brooks and Santosh R Vuppala and Amy M. Jett and Antti Alitalo and Seppo Kalevi Meri and Darrin R. Akins},
  journal={Journal of immunology},
  year={2005},
  volume={175 5},
  pages={
          3299-308
        }
}
Factor H and factor H-like protein 1 (FH/FHL-1) are soluble serum proteins that negatively regulate the alternative pathway of complement. It is now well recognized that many pathogenic bacteria, including Borrelia burgdorferi, bind FH/FHL-1 on their cell surface to evade complement-mediated destruction during infection. Recently, it was suggested that B. burgdorferi open reading frame bbA68, known as complement regulator-acquiring surface protein 1 (CRASP-1), encodes the major FH/FHL-1-binding… CONTINUE READING

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