Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.

@article{Hair2013ComplementRC,
  title={Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.},
  author={Pamela S. Hair and Caitlin K Foley and Neel K Krishna and Julius O Nyalwidhe and Joan A Geoghegan and T. J. Foster and Kenji M Cunnion},
  journal={Results in immunology},
  year={2013},
  volume={3},
  pages={114-21}
}
Staphylococcus aureus is a premier human pathogen and the most common cause of osteoarticular, wound, and implanted device infections. We recently demonstrated S. aureus efficiently binds the classical complement regulator C4b-binding protein (C4BP) inhibiting antibody-initiated complement-mediated opsonization. Here we identify S. aureus surface protein SdrE as a C4BP-binding protein. Recombinant SdrE and recombinant bone sialoprotein-binding protein (Bbp), an allelic variant of SdrE, both… CONTINUE READING
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