Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells.

@article{Nakano2015ComplementRC,
  title={Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells.},
  author={Hideki Nakano and Timothy P Moran and Keiko Nakano and Kevin E. Gerrish and Carl D. Bortner and Donald N. Cook},
  journal={Journal of immunology},
  year={2015},
  volume={194 8},
  pages={3808-19}
}
Differential display of the integrins CD103 and CD11b are widely used to distinguish two major dendritic cell (DC) subsets in nonlymphoid tissues. CD103(+) DCs arise from FLT3-dependent DC precursors (preDCs), whereas CD11b(hi) DCs can arise either from preDCs or FLT3-independent monocytes. Functional characterization of these two lineages of CD11b(hi) DCs has been hindered by the lack of a widely applicable method to distinguish between them. We performed gene expression analysis of… CONTINUE READING
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