Complement protein C1q recognizes a conformationally modified form of the prion protein.

@article{BlanquetGrossard2005ComplementPC,
  title={Complement protein C1q recognizes a conformationally modified form of the prion protein.},
  author={Françoise Blanquet-Grossard and Nicole M Thielens and Charlotte Vendrely and Marc Jamin and G{\'e}rard J. Arlaud},
  journal={Biochemistry},
  year={2005},
  volume={44 11},
  pages={4349-56}
}
Several studies have suggested the implication of the classical complement pathway in the early stages of prion disease pathogenesis. To explore this hypothesis, surface plasmon resonance spectroscopy was used to test the ability of human C1q to recognize mouse PrP immobilized on a sensor chip. In this configuration, C1q bound avidly to PrP, with a K(D) of 5.4 nM (k(on) = 2.4 x 10(5) M(-1) s(-1); k(off) = 1.3 x 10(-3) s(-1)). The isolated C1q globular domain also bound to immobilized PrP… CONTINUE READING

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