Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production.

@article{Fang2009ComplementPT,
  title={Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production.},
  author={Chongyun Fang and Xinhua Zhang and Takashi Miwa and Wen-chao Song},
  journal={Blood},
  year={2009},
  volume={114 5},
  pages={1005-15}
}
Toll-like receptors (TLRs) and complement are 2 major components of innate immunity that provide a first-line host defense and shape the adaptive immune responses. We show here that coincidental activation of complement and several TLRs in mice led to the synergistic production of serum factors that promoted T-helper cell 17 (Th17) differentiation from anti… CONTINUE READING