Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells.

@article{elLati1994ComplementPC,
  title={Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells.},
  author={S G el-Lati and Clemens Andreas Dahinden and M K Church},
  journal={The Journal of investigative dermatology},
  year={1994},
  volume={102 5},
  pages={803-6}
}
The complement peptides C3a and C5a have been shown previously to release histamine from human basophils but not human lung mast cells. As skin mast cells differ from those of the lung in both immunocytochemical and functional properties, we examined the ability of these anaphylatoxins to release preformed and newly generated mediators from human dispersed skin mast cells. In concentration-response studies, both C3a and C5a released histamine in a concentration related manner with C5a being 40… CONTINUE READING

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