Complement mediated renal inflammation induced by donor brain death: role of renal C5a-C5aR interaction.

  title={Complement mediated renal inflammation induced by donor brain death: role of renal C5a-C5aR interaction.},
  author={Maaike B van Werkhoven and Jeffrey J Damman and Marcory R. C. F. van Dijk and Mohamed R. Daha and Igle Jan de Jong and Anna Maria Leliveld and Christina Krikke and Henri G. D. Leuvenink and Harry van Goor and Willem van Son and Peter Olinga and J-L Hillebrands and Marc A. J. Seelen},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  volume={13 4},
Kidneys retrieved from brain-dead donors have impaired allograft function after transplantation compared to kidneys from living donors. Donor brain death (BD) triggers inflammatory responses, including both systemic and local complement activation. The mechanism by which systemic activated complement contributes to allograft injury remains to be elucidated. The aim of this study was to investigate systemic C5a release after BD in human donors and direct effects of C5a on human renal tissue. C5a… CONTINUE READING

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in the recipient

  • MB vanWerkhoven, J Damman, MR Daha
  • 2011

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