Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.

@article{Ruan2015ComplementmediatedMP,
  title={Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.},
  author={Cheng-Chao Ruan and Qian Ge and Yan Li and Xiaodong Li and Dong-Rui Chen and Kai-da Ji and Yong-jie Wu and Li-Juan Sheng and Chen Yan and Dingliang L Zhu and Ping-jin Gao},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 3},
  pages={598-606}
}
OBJECTIVE We have previously shown an increased expression of complement 3 (C3) in the perivascular adipose tissue (PVAT) in the deoxycorticosterone acetate (DOCA)-salt hypertensive model. This study aims to examine the role and underlying mechanism of C3 in PVAT for understanding the pathogenesis of hypertensive vascular remodeling further. APPROACH AND RESULTS The role of C3 in macrophage polarization was investigated using peritoneal macrophages from wild-type and C3-deficient (C3KO) mice… CONTINUE READING
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