Complement is activated in progressive multiple sclerosis cortical grey matter lesions

@inproceedings{Watkins2016ComplementIA,
  title={Complement is activated in progressive multiple sclerosis cortical grey matter lesions},
  author={Lewis M. Watkins and James William Neal and Sam Loveless and Iliana Michailidou and Valeria Ramaglia and Mark Ian Rees and R Reynolds and Neil P. Robertson and B. Paul Morgan and Owain W. Howell},
  booktitle={Journal of Neuroinflammation},
  year={2016}
}
The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining pathological mechanisms at play in MS grey matter is therefore a key to our understanding of disease progression. We analysed complement expression and activation by immunocytochemistry and in situ… CONTINUE READING