Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats.

@article{Proctor2006ComplementIS,
  title={Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats.},
  author={Lavinia M Proctor and Anna J. Strachan and Trent M Woodruff and Indumathy B Mahadevan and H Ming Williams and Ian A. Shiels and Stephen M. Taylor},
  journal={International immunopharmacology},
  year={2006},
  volume={6 8},
  pages={1224-32}
}
Systemic activation of complement is a pathophysiological response common to severe disturbances such as hemorrhagic shock, major burn injury and sepsis. Intravenous infusion of cobra venom factor (CVF) has been used as an animal model of acute respiratory distress syndrome (ARDS), and reliably and selectively induces rapid intravascular activation of the complement system, leading to acute organ damage. In the present study, we have used different complement inhibitors to investigate the roles… CONTINUE READING

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