Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix.

@article{Happonen2009ComplementIC,
  title={Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix.},
  author={Kaisa E. Happonen and Andreas P. Sj{\"o}berg and Matthias M{\"o}rgelin and Dick Heineg{\aa}rd and Anna M. Blom},
  journal={Journal of immunology},
  year={2009},
  volume={182 3},
  pages={
          1518-25
        }
}
Components derived from cartilage have been suggested to maintain the inflammation in joints in arthritis. Small leucine-rich repeat proteins (SLRPs) are structural components of cartilage important in organizing the meshwork of extracellular matrix components. It has recently been shown that the SLRP fibromodulin interacts with complement initiator C1q, leading to complement activation. The complement response is limited since fibromodulin also interacts with the complement inhibitor factor H… CONTINUE READING
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