Corpus ID: 89858365

Complement in neuroinflammation : Studies in leprosy and Amyotrophic Lateral Sclerosis

  title={Complement in neuroinflammation : Studies in leprosy and Amyotrophic Lateral Sclerosis},
  author={N. Idrissi},
The complement system is a part of the innate immunity, and plays an important role in host immunity and inflammation. We previously identified the terminal membrane attack complex (MAC) of the complement system as a key determinant of neurodegeneration and demonstrated that its inhibition is neuroprotective. Besides being part of a mechanism of defence to invading pathogens, MAC has the capacity to cause damage to self-cells and is consequently implicated in many diseases. I describe studies… Expand

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