Complement in immune and inflammatory disorders: pathophysiological mechanisms.

  title={Complement in immune and inflammatory disorders: pathophysiological mechanisms.},
  author={Daniel Ricklin and John D. Lambris},
  journal={Journal of immunology},
  volume={190 8},
Although acute or chronic inflammation is a common component of many clinical disorders, the underlying processes can be highly distinct. In recent years, the complement system has been associated with a growing number of immunological and inflammatory conditions that include degenerative diseases, cancer, and transplant rejection. It becomes evident that excessive activation or insufficient control of complement activation on host cells can cause an immune imbalance that may fuel a vicious… CONTINUE READING
125 Citations
4 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 125 extracted citations


Publications referenced by this paper.
Showing 1-4 of 4 references

Reichner 4149 Fibrin Facilitates Both Innate and T Cell–Mediated Defense against Yersinia pestis Deyan Luo

  • Angel S Byrd, M O Xian, Courtney M Brien, Liz M Johnson, Jonathan S Lavigne
  • Reichner 4149 Fibrin Facilitates Both Innate and…

Sarkar 4408 Epithelial–Mesenchymal Transition Induces an Antitumor Immune Response Mediated by NKG2D Receptor Karin Söderlund Leifler

  • Laura M Rogers, Alicia K Olivier, +12 authors Mary C Penninger
  • Adaptive Immunity Does Not Strongly Suppress…

Sheng-Hao Chuang, Ming-I Yen, and Ching-Tai Huang INNATE IMMUNITY AND INFLAMMATION 4215 Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in

  • Avijit Dutta, Shi-Chuen, +6 authors He
  • Ward, and Markus Huber-Lang 4226 Selective…

Similar Papers

Loading similar papers…