Complement in immune and inflammatory disorders: pathophysiological mechanisms.

@article{Ricklin2013ComplementII,
  title={Complement in immune and inflammatory disorders: pathophysiological mechanisms.},
  author={Daniel Ricklin and John D. Lambris},
  journal={Journal of immunology},
  year={2013},
  volume={190 8},
  pages={3831-8}
}
Although acute or chronic inflammation is a common component of many clinical disorders, the underlying processes can be highly distinct. In recent years, the complement system has been associated with a growing number of immunological and inflammatory conditions that include degenerative diseases, cancer, and transplant rejection. It becomes evident that excessive activation or insufficient control of complement activation on host cells can cause an immune imbalance that may fuel a vicious… CONTINUE READING
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