Complement in atherosclerosis: friend or foe?

  title={Complement in atherosclerosis: friend or foe?},
  author={Walter Stefan Speidl and Stefan Peter Kastl and Kurt Huber and Johann Wojta},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={9 3},
Atherosclerosis is a chronic inflammatory disease and the complement system plays a central role in innate immunity. Increasing evidence exists that the complement system is activated within atherosclerotic plaques. However, the role of complement in atherogenesis is not fully understood. Whereas complement activation by the classic and lectin pathway may be protective by removing apoptotic cells and cell debris from atherosclerotic plaques, activation of the complement cascade by the… CONTINUE READING


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