Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma.

@article{Krug2001ComplementFC,
  title={Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma.},
  author={Norbert Krug and Thomas Tschernig and Veit Johannes Erpenbeck and J M Hohlfeld and Joerg Koehl},
  journal={American journal of respiratory and critical care medicine},
  year={2001},
  volume={164 10 Pt 1},
  pages={1841-3}
}
Allergic asthma is thought to be the result of an inappropriate specific immune response against common environmental antigens. However, studies of animal asthma models have also linked the innate immune system, in particular complement factors C3a and C5, to murine airway hyperresponsiveness. Because the possible role of these anaphylatoxins in patients with asthma is not understood, we tested the hypothesis that C3a and C5a will increase in the bronchoalveolar lavage (BAL) fluid of patients… CONTINUE READING

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