Complement factors C1q and C3b in brains with Creutzfeldt-Jakob disease.

@article{NawrockaKunecka2005ComplementFC,
  title={Complement factors C1q and C3b in brains with Creutzfeldt-Jakob disease.},
  author={Agnieszka Nawrocka-Kunecka and Wielisław Papierz and Paweł P Liberski},
  journal={Polish journal of pathology : official journal of the Polish Society of Pathologists},
  year={2005},
  volume={56 3},
  pages={
          127-9
        }
}
Neuronal loss in Creutzfeldt-Jakob disease (CJD) is due to apoptosis and autophagy, however the apoptotic cell death may be related to the influence of cytokines. The role of complement system in induction of this process was recently postulated. In our study we examined the immunoreactivity for "early activation" complement factors C1q and C3b in the brains of the patients with CJD. We showed the positive immunoreactivity for C1q and C3b in neurons mainly in areas of spongiform change, in… CONTINUE READING