Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration.

@article{Despriet2006ComplementFH,
  title={Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration.},
  author={Dominiek D. G. Despriet and Caroline C W Klaver and Jacqueline C. M. Witteman and Arthur A. B. Bergen and Isabella Kardys and Moniek P M de Maat and Sharmila S. Boekhoorn and Johannes R. Vingerling and Albert Hofman and Ben A. Oostra and Andr{\'e} G. Uitterlinden and Theo Stijnen and Cornelia M. van Duijn and Paulus T V M de Jong},
  journal={JAMA},
  year={2006},
  volume={296 3},
  pages={
          301-9
        }
}
CONTEXT The evidence that inflammation is an important pathway in age-related macular degeneration (AMD) is growing. Recent case-control studies demonstrated an association between the complement factor H (CFH) gene, a regulator of complement, and AMD. OBJECTIVES To assess the associations between the CFH gene and AMD in the general population and to investigate the modifying effect of smoking, serum inflammatory markers, and genetic variation of C-reactive protein (CRP). DESIGN, SETTING… CONTINUE READING

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