Complement factor H modulates the activation of human neutrophil granulocytes and the generation of neutrophil extracellular traps.

@article{Schneider2016ComplementFH,
  title={Complement factor H modulates the activation of human neutrophil granulocytes and the generation of neutrophil extracellular traps.},
  author={Andrea E Schneider and No{\'e}mi S{\'a}ndor and {\'E}va K{\'a}rp{\'a}ti and Mih{\'a}ly J{\'o}zsi},
  journal={Molecular immunology},
  year={2016},
  volume={72},
  pages={37-48}
}
Factor H (FH) is a major inhibitor of the alternative pathway of complement activation in plasma and on certain host surfaces. In addition to being a complement regulator, FH can bind to various cells via specific receptors, including binding to neutrophil granulocytes through complement receptor type 3 (CR3; CD11b/CD18), and modulate their function. The cellular roles of FH are, however, poorly understood. Because neutrophils are important innate immune cells in inflammatory processes and the… CONTINUE READING
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