Complement factor H family proteins in their non-canonical role as modulators of cellular functions.

@article{Jzsi2018ComplementFH,
  title={Complement factor H family proteins in their non-canonical role as modulators of cellular functions.},
  author={Mih{\'a}ly J{\'o}zsi and Andrea E Schneider and {\'E}va K{\'a}rp{\'a}ti and No{\'e}mi S{\'a}ndor},
  journal={Seminars in cell & developmental biology},
  year={2018},
  volume={85},
  pages={
          122-131
        }
}
Complement factor H is a major regulator of the alternative pathway of the complement system. The factor H-related proteins are less characterized, but recent data indicate that they rather promote complement activation. These proteins have some common ligands with factor H and have both overlapping and distinct functions depending on domain composition and the degree of conservation of amino acid sequence. Factor H and some of the factor H-related proteins also appear in a non-canonical… CONTINUE READING