Complement factor H autoantibodies are associated with early stage NSCLC.

@article{Amornsiripanitch2010ComplementFH,
  title={Complement factor H autoantibodies are associated with early stage NSCLC.},
  author={Nita Amornsiripanitch and Shaolin Hong and Michael J. Campa and Mike Frank and Elizabeth B. Gottlin and Edward F. Patz},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 12},
  pages={3226-31}
}
PURPOSE To discover diagnostic biomarkers associated with early-stage non-small cell lung cancer (NSCLC), we searched for autoantibodies preferentially present in stage I patients compared with patients with advanced-stage disease. Here we describe an autoantibody against complement factor H (CFH) and this autoantibody's association with early-stage NSCLC. EXPERIMENTAL DESIGN Immunoblots were used to detect autoantibodies in the sera of stage I NSCLC patients. An autoantibody recognizing a… CONTINUE READING

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