Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women.

@article{Pai2007ComplementFH,
  title={Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and women.},
  author={Jennifer Pai and Joann E. Manson and Kathryn M. Rexrode and Christine M. Albert and David J. Hunter and Eric B. Rimm},
  journal={European heart journal},
  year={2007},
  volume={28 11},
  pages={1297-303}
}
AIMS Complement factor H (CFH) Y402H polymorphism is located in a region that binds C-reactive protein and may affect inflammatory processes and risk of coronary heart disease (CHD). We assessed the association between Y402H and risk of CHD in nested case-control studies among two large prospective cohorts of US male health professionals and female nurses. METHODS AND RESULTS Among participants who were disease-free at baseline, we confirmed 266 (men) and 249 (women) incident CHD deaths and… CONTINUE READING