Complement-endothelial cell interactions: pathophysiological implications.

  title={Complement-endothelial cell interactions: pathophysiological implications.},
  author={Francesco Saverio Tedesco and Fabio Fischetti and Mario Pausa and A. Dobrina and Robert B Sim and Mohamed R. Daha},
  journal={Molecular immunology},
  volume={36 4-5},
The function of the endothelial cells can be modulated by humoral factors present in the circulation and in the extravascular fluid, including proteins of the complement system. This review examines the multiple interactions between the complement system and the endothelial cells and their functional consequences on inflammation, coagulation and regulation of vascular tone. The implications of these interactions in the induction and progression of the vascular lesions occurring in… CONTINUE READING

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