Complement dysfunction in hemolytic uremic syndrome.

  title={Complement dysfunction in hemolytic uremic syndrome.},
  author={Peter F Zipfel and Christine Skerka},
  journal={Current opinion in rheumatology},
  volume={18 5},
PURPOSE OF REVIEW Hemolytic uremic syndrome is a rare disease of microangiopathic hemolytic anemia, low platelet count and is associated with renal impairment. The atypical form, which occurs in adult patients, is associated with defective complement control. RECENT FINDINGS Recent data show that atypical hemolytic uremic syndrome is a genetic disease and gene mutations have been reported for factor H, membrane cofactor protein/CD46 and factor I. All corresponding gene products act in concert… CONTINUE READING


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