Complement-dependent binding of C-reactive protein complexes to human erythrocyte CR1.

@article{Mold1996ComplementdependentBO,
  title={Complement-dependent binding of C-reactive protein complexes to human erythrocyte CR1.},
  author={Carolyn Mold and C Gurul{\'e} and Dennis Otero and Terry W. Du Clos},
  journal={Clinical immunology and immunopathology},
  year={1996},
  volume={81 2},
  pages={153-60}
}
C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) on phospholipids and polysaccharides and to protein components of chromatin and small nuclear ribonucleoproteins. Complexes between CRP and ligands activate complement and bind to receptors on phagocytic cells. Although complement is required for CRP-mediated clearance or phagocytosis of ligand-coated erythrocytes, the participation of complement and complement receptors in clearance of soluble CRP… CONTINUE READING