Complement-dependent P-selectin expression and injury following ischemic stroke.

  title={Complement-dependent P-selectin expression and injury following ischemic stroke.},
  author={C Scott Atkinson and H Lily Zhu and Fei Qiao and Juan Carlos Sosa Varela and Jin Yu and Hongbin Song and Mark S Kindy and Stephen Tomlinson},
  journal={Journal of immunology},
  volume={177 10},
The mechanisms that contribute to inflammatory damage following ischemic stroke are poorly characterized, but studies indicate a role for both complement and P-selectin. In this study, we show that compared with wild-type mice, C3-deficient mice showed significant improvement in survival, neurological deficit, and infarct size at 24 h after middle cerebral artery occlusion and reperfusion. Furthermore, P-selectin protein expression was undetectable in the cerebral microvasculature of C3… CONTINUE READING
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