Complement-dependent Clearance of Apoptotic Cells by Human Macrophages

@article{Mevorach1998ComplementdependentCO,
  title={Complement-dependent Clearance of  Apoptotic Cells by Human Macrophages },
  author={Dror Mevorach and John O. Mascarenhas and Debra Gershov and Keith B Elkon},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={2313 - 2320}
}
Apoptotic cells are rapidly engulfed by phagocytes, but the receptors and ligands responsible for this phenomenon are incompletely characterized. Previously described receptors on blood- derived macrophages have been characterized in the absence of serum and show a relatively low uptake of apoptotic cells. Addition of serum to the phagocytosis assays increased the uptake of apoptotic cells by more than threefold. The serum factors responsible for enhanced uptake were identified as complement… CONTINUE READING

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