Complement consumption in children with Plasmodium falciparum malaria

@article{Nyakoe2008ComplementCI,
  title={Complement consumption in children with Plasmodium falciparum malaria},
  author={Nancy K. Nyakoe and Ronald P Taylor and Joseph N. Makumi and John N Waitumbi},
  journal={Malaria Journal},
  year={2008},
  volume={8},
  pages={7 - 7}
}
Complement (C) can be activated during malaria, C components consumed and inflammatory mediators produced. This has potential to impair host innate defence. In a case-control study, C activation was assessed by measuring serum haemolytic activity (CH50), functional activity of each pathway and levels of C3a, C4a and C5a in children presenting at Kisumu District Hospital, western Kenya, with severe malarial anaemia (SMA) or uncomplicated malaria (UM). CH50 median titers for lysis of sensitized… CONTINUE READING

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