Complement component deposition in uteroplacental (spiral) arteries in normal human pregnancy.

@article{Wells1987ComplementCD,
  title={Complement component deposition in uteroplacental (spiral) arteries in normal human pregnancy.},
  author={Michael Wells and Jean Bennett and Judith N. Bulmer and Paul Jackson and C. S. Holgate},
  journal={Journal of reproductive immunology},
  year={1987},
  volume={12 2},
  pages={125-35}
}
There is conflicting evidence for the deposition of complement in spiral arteries in normal and abnormal human pregnancies. The immunogold silver staining (IGSS) technique was used to investigate the distribution of C1q, C3d, C4, C6 and C9 within the spiral arteries of formalin-fixed normal pregnancy hysterectomy specimens ranging in gestational age from 4 to 40 weeks. Deposition of complement components studied was observed in all cases suggesting classical pathway activation. Reactivity was… CONTINUE READING