Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain


The complement system is becoming increasingly recognized as a key participant in many neurodegenerative diseases of the brain. Complement-deficient animals exhibit reduced neuroinflammation. In the present study, we administered intracerebroventricularly lipopolysaccharide (LPS) to mimic local infection of the brain and investigated the role of key… (More)
DOI: 10.1186/s12974-016-0485-y


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