Complement biosynthesis in the central nervous system.

  title={Complement biosynthesis in the central nervous system.},
  author={Scott Robert Barnum},
  journal={Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists},
  volume={6 2},
Complement is an important effector arm of the human immune response. Binding of proteolytic fragments derived from activation of complement by specific receptors leads to responses as diverse as inflammation, opsonization, and B-cell activation. The importance of characterizing the expression and regulation of complement in the CNS is highlighted by growing evidence that complement plays a significant role in the pathogenesis of a variety of neurological diseases, such as multiple sclerosis… CONTINUE READING


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