Complement binding by two developmental stages of Leishmania major promastigotes varying in expression of a surface lipophosphoglycan

@article{Puentes1988ComplementBB,
  title={Complement binding by two developmental stages of Leishmania major promastigotes varying in expression of a surface lipophosphoglycan},
  author={S M Puentes and David L Sacks and Reginaldo Pereira da Silva and Keith A. Joiner},
  journal={The Journal of Experimental Medicine},
  year={1988},
  volume={167},
  pages={887 - 902}
}
The binding of complement by two developmentally distinct stages of Leishmania major has been studied. Noninfective log phase growth (LOG) promastigotes (serum sensitive) activate complement with deposition of covalently bound C3b onto the surface of the parasite. Infective, peanut agglutinin (PNA-) metacyclic stage promastigotes (serum resistant) also bear mainly C3b after incubation in serum, but a major portion of deposited C3 is present as a 110 X 10(3) mol wt C3 fragment. Whereas… CONTINUE READING