Complement and the multifaceted functions of VWA and integrin I domains.

@article{Springer2006ComplementAT,
  title={Complement and the multifaceted functions of VWA and integrin I domains.},
  author={Timothy A Springer},
  journal={Structure},
  year={2006},
  volume={14 11},
  pages={1611-6}
}
The recent crystal structure of complement protein component C2a reveals an interface between its VWA and serine protease domains that could not exist in the zymogen C2. The implied change in VWA domain conformation between C2 and C2a differs from that described for other VWA domains, including the I domains in integrins. Here, the remarkable diversity in both conformational regulation and ligand binding among VWA domains that function in complement, hemostasis, cell adhesion, anthrax toxin… CONTINUE READING

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References

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Showing 1-10 of 22 references

The human complement system: assembly of the classical pathway C3 convertase.

The Biochemical journal • 1980
View 6 Excerpts
Highly Influenced

Structural basis of integrin regulation and signaling

Luo, B.-H, C. V. Carman, T. A. Springer
Annu. Rev. Immunol., • 2006
View 6 Excerpts
Highly Influenced

Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation

A. A. Bhattacharya, M. L. Lupher, Jr., D. E. Staunton, R. C. Liddington
Structure • 2004
View 3 Excerpts

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