Complement and microglia mediate early synapse loss in Alzheimer mouse models

  title={Complement and microglia mediate early synapse loss in Alzheimer mouse models},
  author={Soyon Hong and Victoria F. Beja-Glasser and Bianca M. Nfonoyim and Arnaud Frouin and Shaomin Li and Saranya Ramakrishnan and Katherine M. Merry and Qiaoqiao Shi and Arnon Rosenthal and Ben A Barres and Cynthia A Lemere and Dennis J Selkoe and Beth Stevens},
Synapse loss in Alzheimer’s disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we show in mouse models that complement and microglia mediate synaptic loss early in AD. C1q, the initiating protein of the classical complement cascade, is increased and associated with synapses before overt plaque deposition. Inhibition of C1q, C3, or the microglial complement receptor CR3 reduces… CONTINUE READING
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