Complement and microglia mediate early synapse loss in Alzheimer mouse models.


Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we show in mouse models that complement and microglia mediate synaptic loss early in AD. C1q, the initiating protein of the classical complement cascade, is… (More)
DOI: 10.1126/science.aad8373


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