Complement and complement regulatory proteins as potential molecular targets for vascular diseases.

@article{Acosta2004ComplementAC,
  title={Complement and complement regulatory proteins as potential molecular targets for vascular diseases.},
  author={Juan Acosta and Xuebin Qin and Jose A Halperin},
  journal={Current pharmaceutical design},
  year={2004},
  volume={10 2},
  pages={
          203-11
        }
}
By-products of complement activation and complement regulatory proteins are increasingly recognized to play an important pathogenic role in a variety of vascular diseases including atherosclerosis, ischemia and reperfusion injury, hyperacute graft rejection, vasculitis, and the vascular complications of human diabetes. "Self" damage by autologous complement is mediated by activation products of the complement cascades or by direct insertion of the membrane attack complex (MAC) into cell… CONTINUE READING
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