Complement and Renal Transplantation: From Donor to Recipient

@article{Damman2008ComplementAR,
  title={Complement and Renal Transplantation: From Donor to Recipient},
  author={Jeffrey Damman and Theo A. Schuurs and Rutger J Ploeg and Marc A.J. Seelen},
  journal={Transplantation},
  year={2008},
  volume={85},
  pages={923-927}
}
Long-term kidney graft survival is affected by different variables including donor condition, ischemia-reperfusion injury, and graft rejection during the transplantation process. The complement system is an important mediator of renal ischemia-reperfusion injury and in rejecting allografts. However, donor complement C3 seems to be crucial in renal transplantation-related injury as renal injury is attenuated in C3 deficient kidney grafts. Interestingly, before ischemia-reperfusion induced C3… 
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Ischemia-reperfusion injury in kidney transplantation.
Ischemia-reperfusion injury to the kidney is a complex pathophysiological process that has importance during transplantation as it affects graft function and survival. It starts with the…
Role of Complement System in Kidney Transplantation: Stepping From Animal Models to Clinical Application
TLDR
The updated understanding of the complement system in kidney transplantation is provided and the existing and upcoming attempts to improve allograft outcomes in animal models and in the clinical setting by targeting the complement System are introduced.
Complement‐mediated inflammation and injury in brain dead organ donors
The Role of Complement in Organ Transplantation
TLDR
Therapeutic complement inhibitors may be effective for protecting transplanted organs from several causes of inflammatory injury and several anti-complement drugs have shown promise in selected patients, but the role of these drugs in transplantation medicine requires further study.
Clinical analysis of perioperative complement activity during ischemia/reperfusion injury following renal transplantation.
TLDR
A role for the complement cascade in delayed graft function development is supported and perioperative measurements of C5b-9/membrane attack complex are highlighted as promising potential clinical markers of post-transplant renal allograft function.
The effect of ischemia/reperfusion on the kidney graft
TLDR
It is of particular importance in kidney transplantation to understand the underlying mechanisms and effects of ischemia/reperfusion on the graft as this knowledge also opens strategies to prevent or treat ischemial injury after transplantation in order to improve graft outcome.
Complement in renal transplantation: The road to translation
Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation.
  • J. Damman, W. Nijboer, +6 authors M. Seelen
  • Medicine, Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2011
TLDR
Targeting renal APPs in brain-dead donors, especially complement C3, may improve transplant outcome, as C3 expression is associated with a worse allograft function early after transplantation.
Donor Brain Death Exacerbates Complement-Dependent Ischemia/Reperfusion Injury in Transplanted Hearts
TLDR
BD exacerbates posttransplantation cardiac ischemia/reperfusion injury in mice and humans and decreases survival of mouse allografts, and targeted complement inhibition in recipients of BD donor hearts ameliorates BD-exacerbated ischemIA/rePerfusions injury.
Targeted donor complement blockade after brain death prevents delayed graft function in a nonhuman primate model of kidney transplantation
  • J. S. Danobeitia, Tiffany J Zens, +20 authors L. Fernandez
  • Medicine, Biology
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2020
TLDR
It is indicated that donor‐management targeting complement activation prevents the development of delayed graft function in BD‐induced renal injury and postulate complement blockade as a promising strategy for the prevention of DGF after transplantation.
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