Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis.

@article{Zhang2016ComplementAR,
  title={Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis.},
  author={Lingjun Zhang and Brent A. Bell and Minzhong Yu and Chi-Chao Chan and Neal S Peachey and John . Fung and Xiaoming Zhang and Rachel R Caspi and Feng Lin},
  journal={Journal of leukocyte biology},
  year={2016},
  volume={99 3},
  pages={447-54}
}
Recent studies have suggested that reagents inhibiting complement activation could be effective in treating T cell mediated autoimmune diseases such as autoimmune uveitis. However, the precise role of the complement anaphylatoxin receptors (C3a and C5a receptors) in the pathogenesis of autoimmune uveitis remains elusive and controversial. We induced… CONTINUE READING