Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death.

@article{Beek2001ComplementAC,
  title={Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death.},
  author={Johan van Beek and Olivier Nicole and C. Rubina Ali and Alexander M. Ischenko and Eric T Mackenzie and Alain Buisson and Marc Fontaine},
  journal={Neuroreport},
  year={2001},
  volume={12 2},
  pages={
          289-93
        }
}
The anaphylatoxin C3a is a potent inflammatory polypeptide released at sites of complement activation. To test whether C3a might alter neuronal outcome following an ischemic insult, we determined the effects of purified human C3a on murine primary cortical cell cultures exposed to apoptotic or excitotoxic paradigms. C3a prevented neither serum deprivation-induced apoptotic neuronal death, nor AMPA/kainate-mediated excitotoxicity. However, in mixed cultures of neurons and astrocytes, C3a dose… CONTINUE READING
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