Complement activation in muscle fiber necrosis: demonstration of the membrane attack complex of complement in necrotic fibers.


The membranolytic C5b-9 complement membrane attach complex (MAC) is assembled after activation of either the classic or the alternative complement pathway. The quaternary configuration of the MAC macromolecule presents neoantigenic determinants not present on precursor molecules. Consequently, antibodies specific for these neoantigen(s) do not detect… (More)


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