Complement activation in diseases presenting with thrombotic microangiopathy.

@article{Meri2013ComplementAI,
  title={Complement activation in diseases presenting with thrombotic microangiopathy.},
  author={Seppo Meri},
  journal={European journal of internal medicine},
  year={2013},
  volume={24 6},
  pages={496-502}
}
The complement system contains a great deal of biological "energy". This is demonstrated by the atypical hemolytic uremic syndrome (aHUS), which is a thrombotic microangiopathy (TMA) characterized by endothelial and blood cell damage and thrombotic vascular occlusions. Kidneys and often also other organs (brain, lungs and gastrointestinal tract) are affected. A principal pathophysiological feature in aHUS is a complement attack against endothelial cells and blood cells. This leads to platelet… CONTINUE READING

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