Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries.

@article{Collins1999ComplementAI,
  title={Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries.},
  author={Angela B. Collins and Eveline E. Schneeberger and M. Asunci{\'o}n Pascual and Susan L. Saidman and Winfred W. Williams and Nina E Tolkoff-Rubin and A. Benedict Cosimi and Robert B. Colvin},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1999},
  volume={10 10},
  pages={2208-14}
}
The distinction between acute humoral rejection (AHR) and acute cellular rejection (ACR) in renal allografts is therapeutically important, but pathologically difficult. Since AHR is probably mediated by antibodies to the donor endothelium that activate the classical complement pathway, it was hypothesized that peritubular capillary C4d deposition might distinguish this group. Renal biopsies (n = 16) from 10 patients with AHR who had acute graft dysfunction, neutrophils in peritubular… CONTINUE READING