Complement activation contributes to ventilator-induced lung injury in rats.

  title={Complement activation contributes to ventilator-induced lung injury in rats.},
  author={Bodil Petersen and Thilo Busch and J Gaertner and Jack Haitsma and S Krabbendam and Michael Ebsen and Burkhard Lachmann and Udo X. Kaisers},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  volume={67 6},
The complement system contributes to ventilator induced lung injury (VILI). We hypothesized that pretreatment with the C1 esterase inhibitor (C1INH) Berinert® constrains complement activation consecutively inducing improvements in arterial oxygenation and histological pulmonary damage. At baseline, male Sprague-Dawley rats underwent mechanical ventilation in a conventional mode (PIP 13 cm H2O, PEEP 3 cm H2O). In the Control group, the ventilator setting was maintained (Control, n = 15). The… CONTINUE READING