Complement activation by tubular cells is mediated by properdin binding.


Activation of filtered complement products on the brush border of the tubular epithelium is thought to be a key factor underlying proteinuria-induced tubulointerstitial injury. However, the mechanism of tubular complement activation is still unclear. Recent studies on mechanisms of complement activation indicate a key role for properdin in the initiation of… (More)
DOI: 10.1152/ajprenal.90313.2008


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@article{Gaarkeuken2008ComplementAB, title={Complement activation by tubular cells is mediated by properdin binding.}, author={Hilde Gaarkeuken and Machiel A Siezenga and Kim Zuidwijk and Cees van Kooten and Ton J Rabelink and Mohamed R. Daha and Stefan Perkmann Berger}, journal={American journal of physiology. Renal physiology}, year={2008}, volume={295 5}, pages={F1397-403} }