Complement activation by apoptotic cells occurs predominantly via IgM and is limited to late apoptotic (secondary necrotic) cells.

@article{Zwart2004ComplementAB,
  title={Complement activation by apoptotic cells occurs predominantly via IgM and is limited to late apoptotic (secondary necrotic) cells.},
  author={Bas Zwart and Caroline L. F. Ciurana and Irma Rensink and Rishi Manoe and C. Erik Hack and Lucien A. Aarden},
  journal={Autoimmunity},
  year={2004},
  volume={37 2},
  pages={
          95-102
        }
}
Apoptotic cells activate complement via various molecular mechanisms. It is not known which of these mechanisms predominate in a physiological environment. Using Jurkat cells as a model, we investigated complement deposition on vital, early and late apoptotic (secondary necrotic) cells in a physiological medium, human plasma, and established the main molecular mechanism involved in this activation. Upon incubation with recalcified plasma, binding of C3 and C4 to early apoptotic cells was… CONTINUE READING
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